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Dermal HSA appears as a red or black growth on hairless portions like the abdomen. Dogs with less fur like Dalmatians and Pit bull terriers have a high propensity for this disease. Whereas for the sub-cutaneous and visceral tumors which arise in internal organs, there is often very little warning before the time they cause severe clinical signs. A common estimate of the average time from discovery of the tumor until death occurs in affected dogs is 6 to 8 weeks. The symptoms vary depending on the location of the tumor. It could be from non-specific signs of illness to asymptomatic abdominal swelling, to acute death secondary to hemorrhagic/hypotensive shock. Common symptoms for visceral HSA are acute weakness or collapse. Other signs include lethargy, inappetance (lack of appetite), weight loss, abdominal distension (bloated abdomen), nose bleeding, fatigue, pale color of the mucous membranes of the mouth and the eyes and increased respiratory rates. Dogs with cardiac HSA show signs related to pericardial temponade and associated right-sided heart failure such as exercise intolerance, dyspnea (shortness of breath), and ascites (excessive fluid in the peritoneal cavity), muffled heart sounds and pulses paradoxus (a variation in pulse quality associated with respiration). There is clotting of blood inside the blood vessels called disseminated intra vascular coagulation or DIC. It uses up all of the blood clotting elements quickly and dogs usually have platelet deficiencies, increased blood clotting at times, decrease in fibrin content in the blood and an increase in fibrin degradation products (FDPs). This probably leads to death in most of the cases.

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